Assay Detail
Binding
CHEMBL4817110
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel and potent PARP/PI3K dual inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.38 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4865059 | — | — | 1 | 7.92 |
| CHEMBL4871210 | — | — | 1 | 7.64 |
| CHEMBL4858564 | — | — | 1 | 7.30 |
| CHEMBL4868231 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4865059 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4871210 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4858564 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4868231 | — | IC50 | = | 216.0 | nM | 6.67 |