Assay Detail
Functional
CHEMBL4817162
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Antiproliferative activity against human A549 cells assessed as growth inhibition by CCK8 assay
30
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Epithelial cell |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.19 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.35 |
| CHEMBL4861875 | — | — | 3 | 6.19 |
| CHEMBL4536788 | — | — | 1 | 5.78 |
| CHEMBL4861082 | — | — | 1 | 5.68 |
| CHEMBL4872044 | — | — | 1 | 5.67 |
| CHEMBL4846091 | — | — | 1 | 5.61 |
| CHEMBL4869621 | — | — | 1 | 5.42 |
| CHEMBL4865023 | — | — | 1 | 5.28 |
| CHEMBL4857712 | — | — | 1 | 5.10 |
| CHEMBL4868176 | — | — | 1 | 5.03 |
| CHEMBL4860549 | — | — | 1 | 4.93 |
| CHEMBL4877774 | — | — | 1 | 4.93 |
| CHEMBL4853770 | — | — | 1 | 4.92 |
| CHEMBL4868265 | — | — | 1 | 4.90 |
| CHEMBL4861889 | — | — | 1 | 4.87 |
| CHEMBL4851982 | — | — | 1 | 4.85 |
| CHEMBL4865282 | — | — | 1 | 4.76 |
| CHEMBL4855200 | — | — | 1 | 4.73 |
| CHEMBL4854257 | — | — | 1 | 4.71 |
| CHEMBL4857625 | — | — | 1 | 4.59 |
| CHEMBL4862126 | — | — | 1 | 4.57 |
| CHEMBL4862430 | — | — | 1 | 4.52 |
| CHEMBL4872190 | — | — | 1 | 4.35 |
| CHEMBL4847110 | — | — | 1 | - |
| CHEMBL4581843 | — | — | 1 | - |
| CHEMBL1986301 | — | — | 1 | - |
| CHEMBL463165 | — | — | 1 | - |
| CHEMBL4852685 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4861875 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4861875 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4536788 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4861082 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL4872044 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL4846091 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL4869621 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4865023 | — | IC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL4857712 | — | IC50 | = | 7910.0 | nM | 5.10 |
| CHEMBL4868176 | — | IC50 | = | 9270.0 | nM | 5.03 |
| CHEMBL4877774 | — | IC50 | = | 11760.0 | nM | 4.93 |
| CHEMBL4860549 | — | IC50 | = | 11860.0 | nM | 4.93 |
| CHEMBL4853770 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4868265 | — | IC50 | = | 12710.0 | nM | 4.90 |
| CHEMBL4861889 | — | IC50 | = | 13570.0 | nM | 4.87 |
| CHEMBL4851982 | — | IC50 | = | 14070.0 | nM | 4.85 |
| CHEMBL4861875 | — | IC50 | = | 16130.0 | nM | 4.79 |
| CHEMBL4865282 | — | IC50 | = | 17410.0 | nM | 4.76 |
| CHEMBL4855200 | — | IC50 | = | 18710.0 | nM | 4.73 |
| CHEMBL4854257 | — | IC50 | = | 19550.0 | nM | 4.71 |
| CHEMBL4857625 | — | IC50 | = | 25490.0 | nM | 4.59 |
| CHEMBL4862126 | — | IC50 | = | 27180.0 | nM | 4.57 |
| CHEMBL4862430 | — | IC50 | = | 30250.0 | nM | 4.52 |
| CHEMBL4872190 | — | IC50 | = | 44630.0 | nM | 4.35 |
| CHEMBL1986301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL463165 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4847110 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4581843 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4852685 | — | IC50 | > | 100000.0 | nM | - |