Assay Detail
ADMET
CHEMBL4817448
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Binding affinity to human serum albumin assessed as dissociation constant by fluorescence emission spectrophotometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Serum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Using porphyrins as albumin-binding molecules to enhance antitumor efficacies and reduce systemic toxicities of antimicrobial peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.36 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL520220 | PYROPHEOPHORBIDE A | — | 1 | 7.05 |
| CHEMBL4850435 | — | — | 1 | 6.44 |
| CHEMBL1200712 | EVANS BLUE | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL520220 | PYROPHEOPHORBIDE A | Kd | = | 89.3 | nM | 7.05 |
| CHEMBL4850435 | — | Kd | = | 363.0 | nM | 6.44 |
| CHEMBL1200712 | EVANS BLUE | Kd | = | 2500.0 | nM | 5.60 |