Assay Detail
Functional
CHEMBL4817541
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Antiproliferative activity against human HEC-1-A cells expressing mutant KRAS assessed as reduction in cell growth incubated for 72 hrs by CyQuant proliferation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEC-1-A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.47 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4859726 | — | — | 1 | 5.64 |
| CHEMBL4854753 | — | — | 1 | 5.64 |
| CHEMBL4858481 | — | — | 1 | 5.58 |
| CHEMBL254832 | FENDILINE | 2.0 | 1 | 5.02 |
| CHEMBL4849536 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4859726 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4854753 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4858481 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL254832 | FENDILINE | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL4849536 | — | IC50 | > | 30000.0 | nM | - |