Assay Detail
Functional
CHEMBL4817794
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Antimalarial activity against Plasmodium falciparum infected in human RBC assessed as reduction in parasite growth measured after 72 hrs by flow cytometry analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | RBC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.24 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4863548 | — | — | 1 | 7.43 |
| CHEMBL4876627 | — | — | 1 | 7.42 |
| CHEMBL4849401 | — | — | 1 | 7.40 |
| CHEMBL4856601 | — | — | 1 | 7.14 |
| CHEMBL4871401 | — | — | 1 | 7.14 |
| CHEMBL4872683 | — | — | 1 | 7.13 |
| CHEMBL532155 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4863548 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4876627 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4849401 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4856601 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4871401 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4872683 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL532155 | — | IC50 | = | 90.0 | nM | 7.05 |