Assay Detail
ADMET
CHEMBL4817951
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Cytotoxicity against human A549 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and antibacterial evaluation of PFK-158 derivatives as potent agents against drug-resistant bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.74 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848247 | — | — | 1 | 5.01 |
| CHEMBL4846888 | — | — | 1 | 4.99 |
| CHEMBL4851092 | — | — | 1 | 4.95 |
| CHEMBL4303611 | PFK-158 | 1.0 | 1 | 4.82 |
| CHEMBL3714967 | — | — | 1 | 4.73 |
| CHEMBL3718600 | — | — | 1 | 4.68 |
| CHEMBL4856429 | — | — | 1 | 4.37 |
| CHEMBL4851028 | — | — | 1 | 4.34 |
| CHEMBL4871123 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848247 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4846888 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL4851092 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL4303611 | PFK-158 | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3714967 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL3718600 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4856429 | — | IC50 | = | 43100.0 | nM | 4.37 |
| CHEMBL4851028 | — | IC50 | = | 45400.0 | nM | 4.34 |
| CHEMBL4871123 | — | IC50 | > | 50000.0 | nM | - |