Assay Detail
Binding
CHEMBL4818247
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Binding affinity to Staphylococcus aureus PBP2a assessed as equilibrium dissociation constant by SPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of novel Staphylococcus aureus penicillin binding protein 2a inhibitors by multistep virtual screening and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.08 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4847813 | — | — | 1 | 6.89 |
| CHEMBL4879273 | — | — | 1 | 6.78 |
| CHEMBL4862632 | — | — | 1 | 6.58 |
| CHEMBL4871381 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4847813 | — | Kd | = | 129.0 | nM | 6.89 |
| CHEMBL4879273 | — | Kd | = | 168.0 | nM | 6.78 |
| CHEMBL4862632 | — | Kd | = | 264.0 | nM | 6.58 |
| CHEMBL4871381 | — | Kd | = | 86600.0 | nM | 4.06 |