Assay Detail
Binding
CHEMBL4818544
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Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of 0.1 % heat inactivated NHS by Steady-Glo luciferase assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 2C4 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.92 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873847 | — | — | 1 | 6.92 |
| CHEMBL2448576 | — | — | 1 | 6.70 |
| CHEMBL4861270 | — | — | 1 | 6.62 |
| CHEMBL4872186 | — | — | 1 | 6.52 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 6.33 |
| CHEMBL4858081 | — | — | 1 | 6.07 |
| CHEMBL4879154 | — | — | 1 | 6.06 |
| CHEMBL4867665 | — | — | 1 | 5.89 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.80 |
| CHEMBL4862719 | — | — | 1 | 4.96 |
| CHEMBL4851511 | — | — | 1 | 4.77 |
| CHEMBL4874919 | — | — | 1 | 4.40 |
| CHEMBL4859130 | — | — | 1 | - |
| CHEMBL4851062 | — | — | 1 | - |
| CHEMBL4855240 | — | — | 1 | - |
| CHEMBL4877454 | — | — | 1 | - |
| CHEMBL4878011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873847 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2448576 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4861270 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4872186 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4858081 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4879154 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4867665 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4862719 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4851511 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4874919 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4859130 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4851062 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4855240 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4877454 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4878011 | — | IC50 | > | 40000.0 | nM | - |