Assay Detail
Binding
CHEMBL4818550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of class 1 HDAC in human Jurkat 2C4 model of HIV latency assessed as reactivation of HIV latency incubated for 18 to 24 hrs in presence of 5% heat inactivated NHS by Steady-Glo luciferase assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 2C4 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.73 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873847 | — | — | 1 | 6.23 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 6.21 |
| CHEMBL2448576 | — | — | 1 | 6.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.72 |
| CHEMBL4861270 | — | — | 1 | 5.50 |
| CHEMBL4879154 | — | — | 1 | 5.32 |
| CHEMBL4867665 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873847 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL2448576 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4861270 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4879154 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4867665 | — | IC50 | = | 7400.0 | nM | 5.13 |