Assay Detail
Binding
CHEMBL4818576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HPK1 (unknown origin) using SLP76 as substrate incubated for 1 hr by TR-FRET assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 1 (CHEMBL5749) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 9.39 | 10.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870155 | — | — | 1 | 10.57 |
| CHEMBL4864568 | — | — | 1 | 10.43 |
| CHEMBL4848845 | — | — | 1 | 10.43 |
| CHEMBL4866139 | — | — | 1 | 10.28 |
| CHEMBL4865305 | — | — | 1 | 10.21 |
| CHEMBL4855158 | — | — | 1 | 10.17 |
| CHEMBL4863492 | — | — | 1 | 10.03 |
| CHEMBL4872743 | — | — | 1 | 9.96 |
| CHEMBL4866616 | — | — | 1 | 9.89 |
| CHEMBL4879259 | — | — | 1 | 9.80 |
| CHEMBL4860645 | — | — | 1 | 9.80 |
| CHEMBL4849567 | — | — | 1 | 9.70 |
| CHEMBL4857184 | — | — | 1 | 9.66 |
| CHEMBL4878586 | — | — | 1 | 9.60 |
| CHEMBL4874375 | — | — | 1 | 9.59 |
| CHEMBL4871382 | — | — | 1 | 9.54 |
| CHEMBL4873035 | — | — | 1 | 9.52 |
| CHEMBL4859773 | — | — | 1 | 9.34 |
| CHEMBL4851277 | — | — | 1 | 9.23 |
| CHEMBL4868682 | — | — | 1 | 9.16 |
| CHEMBL4868487 | — | — | 1 | 9.06 |
| CHEMBL4878650 | — | — | 1 | 8.36 |
| CHEMBL4860928 | — | — | 1 | 8.11 |
| CHEMBL4873991 | — | — | 1 | 8.08 |
| CHEMBL4856183 | — | — | 1 | 7.94 |
| CHEMBL4876320 | — | — | 1 | 7.85 |
| CHEMBL4868527 | — | — | 1 | 7.19 |
| CHEMBL4859451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870155 | — | IC50 | = | 0.027 | nM | 10.57 |
| CHEMBL4864568 | — | IC50 | = | 0.037 | nM | 10.43 |
| CHEMBL4848845 | — | IC50 | = | 0.037 | nM | 10.43 |
| CHEMBL4866139 | — | IC50 | = | 0.052 | nM | 10.28 |
| CHEMBL4865305 | — | IC50 | = | 0.061 | nM | 10.21 |
| CHEMBL4855158 | — | IC50 | = | 0.067 | nM | 10.17 |
| CHEMBL4863492 | — | IC50 | = | 0.094 | nM | 10.03 |
| CHEMBL4872743 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL4866616 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL4879259 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL4860645 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL4849567 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4857184 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL4878586 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL4874375 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL4871382 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL4873035 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4859773 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL4851277 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL4868682 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL4868487 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL4878650 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4860928 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4873991 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4856183 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4876320 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4868527 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4859451 | — | IC50 | = | 0.005 | nM | - |