Assay Detail
Binding
CHEMBL4818577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HPK1 in human PBMC assessed as inhibition of SLP76 phosphorylation incubated for 1 hr by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 1 (CHEMBL5749) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.81 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4848845 | — | — | 1 | 7.50 |
| CHEMBL4865305 | — | — | 1 | 7.11 |
| CHEMBL4878586 | — | — | 1 | 6.34 |
| CHEMBL4868487 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4848845 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4865305 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4878586 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL4868487 | — | IC50 | = | 517.0 | nM | 6.29 |