Assay Detail
ADMET
CHEMBL4818605
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Cytotoxicity against human MRC-5 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.70 | 4.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4851703 | — | — | 1 | 4.70 |
| CHEMBL4864504 | — | — | 1 | - |
| CHEMBL4864325 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4851703 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL4864504 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4864325 | — | IC50 | > | 100000.0 | nM | - |