Assay Detail
Binding
CHEMBL4818608
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Inhibition of OXA-48 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 mins by spectrophotometric analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.23 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4851703 | — | — | 1 | 7.16 |
| CHEMBL4875502 | — | — | 1 | 6.41 |
| CHEMBL4872541 | — | — | 1 | 6.35 |
| CHEMBL4872507 | — | — | 1 | 6.29 |
| CHEMBL4857236 | — | — | 1 | 6.28 |
| CHEMBL4854293 | — | — | 1 | 6.19 |
| CHEMBL4855265 | — | — | 1 | 6.16 |
| CHEMBL4865343 | — | — | 1 | 6.10 |
| CHEMBL4876416 | — | — | 1 | 6.08 |
| CHEMBL4855195 | — | — | 1 | 6.08 |
| CHEMBL4855728 | — | — | 1 | 6.08 |
| CHEMBL4867248 | — | — | 1 | 6.07 |
| CHEMBL4864504 | — | — | 1 | 6.04 |
| CHEMBL4862171 | — | — | 1 | 5.89 |
| CHEMBL4848912 | — | — | 1 | - |
| CHEMBL4853896 | — | — | 1 | - |
| CHEMBL4855927 | — | — | 1 | - |
| CHEMBL4863342 | — | — | 1 | - |
| CHEMBL4871170 | — | — | 1 | - |
| CHEMBL4854773 | — | — | 1 | - |
| CHEMBL4867739 | — | — | 1 | - |
| CHEMBL4876173 | — | — | 1 | - |
| CHEMBL4859607 | — | — | 1 | - |
| CHEMBL4849160 | — | — | 1 | - |
| CHEMBL4852831 | — | — | 1 | - |
| CHEMBL4852004 | — | — | 1 | - |
| CHEMBL4875972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4851703 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4875502 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL4872541 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL4872507 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL4857236 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL4854293 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL4855265 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL4865343 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL4876416 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL4855195 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL4855728 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL4867248 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL4864504 | — | Ki | = | 910.0 | nM | 6.04 |
| CHEMBL4862171 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL4848912 | — | Ki | - | — | - | |
| CHEMBL4853896 | — | Ki | - | — | - | |
| CHEMBL4855927 | — | Ki | - | — | - | |
| CHEMBL4863342 | — | Ki | - | — | - | |
| CHEMBL4871170 | — | Ki | - | — | - | |
| CHEMBL4854773 | — | Ki | - | — | - | |
| CHEMBL4867739 | — | Ki | - | — | - | |
| CHEMBL4876173 | — | Ki | - | — | - | |
| CHEMBL4859607 | — | Ki | - | — | - | |
| CHEMBL4849160 | — | Ki | - | — | - | |
| CHEMBL4852831 | — | Ki | - | — | - | |
| CHEMBL4852004 | — | Ki | - | — | - | |
| CHEMBL4875972 | — | Ki | - | — | - |