Assay Detail
Binding
CHEMBL4818609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KPC-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 mins by spectrophotometric analysis
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of β-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.63 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4851703 | — | — | 1 | 6.55 |
| CHEMBL4877631 | — | — | 1 | 6.14 |
| CHEMBL4867398 | — | — | 1 | 5.94 |
| CHEMBL4862416 | — | — | 1 | 5.85 |
| CHEMBL4868540 | — | — | 1 | 5.85 |
| CHEMBL4855728 | — | — | 1 | 5.81 |
| CHEMBL4867248 | — | — | 1 | 5.80 |
| CHEMBL4876416 | — | — | 1 | 5.75 |
| CHEMBL4855265 | — | — | 1 | 5.74 |
| CHEMBL4855195 | — | — | 1 | 5.74 |
| CHEMBL4864504 | — | — | 1 | 5.72 |
| CHEMBL4848727 | — | — | 1 | 5.71 |
| CHEMBL4860974 | — | — | 1 | 5.71 |
| CHEMBL4862171 | — | — | 1 | 5.66 |
| CHEMBL4866009 | — | — | 1 | 5.63 |
| CHEMBL4865343 | — | — | 1 | 5.62 |
| CHEMBL4855927 | — | — | 1 | 5.44 |
| CHEMBL4849131 | — | — | 1 | 5.44 |
| CHEMBL4849406 | — | — | 1 | 5.44 |
| CHEMBL4864325 | — | — | 1 | 5.43 |
| CHEMBL4848912 | — | — | 1 | 5.41 |
| CHEMBL4876790 | — | — | 1 | 5.41 |
| CHEMBL4853896 | — | — | 1 | 5.38 |
| CHEMBL4875502 | — | — | 1 | 5.28 |
| CHEMBL4872507 | — | — | 1 | 5.25 |
| CHEMBL4854293 | — | — | 1 | 5.22 |
| CHEMBL4872541 | — | — | 1 | 5.19 |
| CHEMBL4852511 | — | — | 1 | - |
| CHEMBL4863342 | — | — | 1 | - |
| CHEMBL4871170 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4851703 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL4877631 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL4867398 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL4862416 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4868540 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL4855728 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL4867248 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL4876416 | — | Ki | = | 1770.0 | nM | 5.75 |
| CHEMBL4855265 | — | Ki | = | 1840.0 | nM | 5.74 |
| CHEMBL4855195 | — | Ki | = | 1810.0 | nM | 5.74 |
| CHEMBL4864504 | — | Ki | = | 1890.0 | nM | 5.72 |
| CHEMBL4848727 | — | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL4860974 | — | Ki | = | 1960.0 | nM | 5.71 |
| CHEMBL4862171 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL4866009 | — | Ki | = | 2360.0 | nM | 5.63 |
| CHEMBL4865343 | — | Ki | = | 2410.0 | nM | 5.62 |
| CHEMBL4849406 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL4855927 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL4849131 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL4864325 | — | Ki | = | 3690.0 | nM | 5.43 |
| CHEMBL4848912 | — | Ki | = | 3890.0 | nM | 5.41 |
| CHEMBL4876790 | — | Ki | = | 3940.0 | nM | 5.41 |
| CHEMBL4853896 | — | Ki | = | 4150.0 | nM | 5.38 |
| CHEMBL4875502 | — | Ki | = | 5230.0 | nM | 5.28 |
| CHEMBL4872507 | — | Ki | = | 5660.0 | nM | 5.25 |
| CHEMBL4854293 | — | Ki | = | 6040.0 | nM | 5.22 |
| CHEMBL4872541 | — | Ki | = | 6490.0 | nM | 5.19 |
| CHEMBL4852831 | — | Ki | - | — | - | |
| CHEMBL4849160 | — | Ki | - | — | - | |
| CHEMBL4876173 | — | Ki | - | — | - | |
| CHEMBL4867739 | — | Ki | - | — | - | |
| CHEMBL4854773 | — | Ki | - | — | - | |
| CHEMBL4852004 | — | Ki | - | — | - | |
| CHEMBL4875972 | — | Ki | - | — | - | |
| CHEMBL4871170 | — | Ki | - | — | - | |
| CHEMBL4863342 | — | Ki | - | — | - | |
| CHEMBL4852511 | — | Ki | - | — | - |