Assay Detail
Binding
CHEMBL4818709
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Inhibition of Plasmodium falciparum HGXPRT using PRib-PP as substrate by Hanes-plot based method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.49 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3394316 | — | — | 1 | 6.72 |
| CHEMBL3394313 | — | — | 1 | 6.70 |
| CHEMBL2420976 | — | — | 1 | 6.40 |
| CHEMBL4845693 | — | — | 1 | 5.70 |
| CHEMBL4846343 | — | — | 1 | 5.70 |
| CHEMBL4857499 | — | — | 1 | 5.52 |
| CHEMBL4878296 | — | — | 1 | 5.33 |
| CHEMBL4864826 | — | — | 1 | 5.30 |
| CHEMBL4871215 | — | — | 1 | 4.82 |
| CHEMBL4873456 | — | — | 1 | 4.77 |
| CHEMBL4865439 | — | — | 1 | 4.52 |
| CHEMBL4864370 | — | — | 1 | 4.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3394316 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL3394313 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL2420976 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL4845693 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4846343 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL4857499 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL4878296 | — | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL4864826 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL4871215 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL4873456 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL4865439 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL4864370 | — | Ki | = | 44000.0 | nM | 4.36 |