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Assay Detail

CHEMBL4818892

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Functional
Antiviral activity against pseudotyped Machupo virus
ChEMBL ↗
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mammarenavirus machupoense
Confidence 1 — Organism
Curated By Autocuration

Target

Machupo mammarenavirus (CHEMBL4888477) ↗
Type ORGANISM
Organism Mammarenavirus machupoense

Publication

Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors.
Plewe MB, Gantla VR, Sokolova NV, Shin YJ, Naik S, Brown ER, Fetsko A, Zhang L, Kalveram B, Freiberg AN, Henkel G, McCormack K.
Bioorg Med Chem Lett (2021) 41 : 127983 -127983
PubMed 33965007 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 49 8.82 9.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4856859 — — 1 9.96
CHEMBL4874618 — — 1 9.92
CHEMBL4853992 — — 1 9.80
CHEMBL4851799 — — 1 9.80
CHEMBL4871373 — — 1 9.77
CHEMBL4871246 — — 1 9.77
CHEMBL4852706 — — 1 9.70
CHEMBL4871905 — — 1 9.68
CHEMBL4858248 — — 1 9.60
CHEMBL4874472 — — 1 9.60
CHEMBL4853959 — — 1 9.47
CHEMBL4868358 — — 1 9.38
CHEMBL4860136 — — 1 9.34
CHEMBL4876761 — — 1 9.33
CHEMBL4854274 — — 1 9.28
CHEMBL4850426 — — 1 9.14
CHEMBL4862001 — — 1 9.12
CHEMBL4852422 — — 1 8.91
CHEMBL4854894 — — 1 8.85
CHEMBL4861968 — — 1 8.78
CHEMBL4860575 — — 1 8.77
CHEMBL4869270 — — 1 8.68
CHEMBL4856591 — — 1 8.63
CHEMBL4864575 — — 1 8.59
CHEMBL4860462 — — 1 8.57
CHEMBL4849095 — — 1 8.57
CHEMBL4861450 — — 1 8.41
CHEMBL4854251 — — 1 8.37
CHEMBL4846159 — — 1 8.28
CHEMBL4853054 — — 1 8.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4856859 — EC50 = 0.11 nM 9.96
CHEMBL4874618 — EC50 = 0.12 nM 9.92
CHEMBL4851799 — EC50 = 0.16 nM 9.80
CHEMBL4853992 — EC50 = 0.16 nM 9.80
CHEMBL4871373 — EC50 = 0.17 nM 9.77
CHEMBL4871246 — EC50 = 0.17 nM 9.77
CHEMBL4852706 — EC50 = 0.2 nM 9.70
CHEMBL4871905 — EC50 = 0.21 nM 9.68
CHEMBL4858248 — EC50 = 0.25 nM 9.60
CHEMBL4874472 — EC50 = 0.25 nM 9.60
CHEMBL4853959 — EC50 = 0.34 nM 9.47
CHEMBL4868358 — EC50 = 0.42 nM 9.38
CHEMBL4860136 — EC50 = 0.46 nM 9.34
CHEMBL4876761 — EC50 = 0.47 nM 9.33
CHEMBL4854274 — EC50 = 0.52 nM 9.28
CHEMBL4850426 — EC50 = 0.72 nM 9.14
CHEMBL4862001 — EC50 = 0.75 nM 9.12
CHEMBL4852422 — EC50 = 1.22 nM 8.91
CHEMBL4854894 — EC50 = 1.4 nM 8.85
CHEMBL4861968 — EC50 = 1.65 nM 8.78
CHEMBL4860575 — EC50 = 1.69 nM 8.77
CHEMBL4869270 — EC50 = 2.09 nM 8.68
CHEMBL4856591 — EC50 = 2.32 nM 8.63
CHEMBL4864575 — EC50 = 2.56 nM 8.59
CHEMBL4860462 — EC50 = 2.7 nM 8.57
CHEMBL4849095 — EC50 = 2.68 nM 8.57
CHEMBL4861450 — EC50 = 3.92 nM 8.41
CHEMBL4854251 — EC50 = 4.27 nM 8.37
CHEMBL4846159 — EC50 = 5.21 nM 8.28
CHEMBL4853054 — EC50 = 5.32 nM 8.27
CHEMBL4865651 — EC50 = 6.56 nM 8.18
CHEMBL4864023 — EC50 = 7.69 nM 8.11
CHEMBL4863098 — EC50 = 12.56 nM 7.90
CHEMBL4869681 — EC50 = 13.96 nM 7.86
CHEMBL4865600 — EC50 = 14.61 nM 7.83
CHEMBL4859320 — EC50 = 18.58 nM 7.73
CHEMBL4849537 — EC50 = 19.55 nM 7.71
CHEMBL4866634 — EC50 = 20.62 nM 7.69
CHEMBL4877127 — EC50 = 20.64 nM 7.68
CHEMBL4854571 — EC50 = 23.94 nM 7.62
CHEMBL4865537 — EC50 > 25.0 nM -
CHEMBL4870517 — EC50 > 25.0 nM -
CHEMBL4865002 — EC50 > 25.0 nM -
CHEMBL4849078 — EC50 > 25.0 nM -
CHEMBL4864499 — EC50 > 25.0 nM -
CHEMBL4870239 — EC50 > 25.0 nM -
CHEMBL4862268 — EC50 > 25.0 nM -
CHEMBL4856500 — EC50 > 25.0 nM -
CHEMBL4874362 — EC50 > 25.0 nM -