Assay Detail
Binding
CHEMBL4819274
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Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chlorine substituents and linker topology as factors of 5-HT<sub>6</sub>R activity for novel highly active 1,3,5-triazine derivatives with procognitive properties in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.40 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860275 | — | — | 1 | 8.22 |
| CHEMBL4873623 | — | — | 1 | 8.22 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 8.15 |
| CHEMBL4876727 | — | — | 1 | 7.96 |
| CHEMBL4858771 | — | — | 1 | 7.92 |
| CHEMBL4846146 | — | — | 1 | 7.89 |
| CHEMBL4855393 | — | — | 1 | 7.80 |
| CHEMBL4864863 | — | — | 1 | 7.77 |
| CHEMBL4847379 | — | — | 1 | 7.68 |
| CHEMBL4869411 | — | — | 1 | 7.64 |
| CHEMBL4447416 | — | — | 1 | 7.64 |
| CHEMBL4864448 | — | — | 1 | 7.58 |
| CHEMBL4860006 | — | — | 1 | 7.57 |
| CHEMBL4849077 | — | — | 1 | 7.29 |
| CHEMBL4873127 | — | — | 1 | 7.14 |
| CHEMBL4857676 | — | — | 1 | 7.07 |
| CHEMBL4861431 | — | — | 1 | 7.02 |
| CHEMBL4860719 | — | — | 1 | 6.56 |
| CHEMBL4849230 | — | — | 1 | 6.33 |
| CHEMBL4867534 | — | — | 1 | 6.00 |
| CHEMBL4868911 | — | — | 1 | 5.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860275 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4873623 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL715 | OLANZAPINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL4876727 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4858771 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4846146 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4855393 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4864863 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL4847379 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4869411 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4447416 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL4864448 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4860006 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL4849077 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4873127 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL4857676 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL4861431 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL4860719 | — | Ki | = | 274.0 | nM | 6.56 |
| CHEMBL4849230 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL4867534 | — | Ki | = | 999.0 | nM | 6.00 |
| CHEMBL4868911 | — | Ki | = | 1061.0 | nM | 5.97 |