Assay Detail

CHEMBL4819302

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Binding

Inhibition of HDAC1 (unknown origin) by color-de-lys assay

ChEMBL ↗

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Target

Histone deacetylase 1 (CHEMBL325) ↗

Open DB target context

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Histone deacetylase 1 (CHEMBL325) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histone deacetylase 1

CHEMBL325

Anchored from Assay target.

Protein identity Histone deacetylase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Histone deacetylase 1 (CHEMBL325) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment.

Peng X, Sun Z, Kuang P, Chen J.
Eur J Med Chem (2020) 208 : 112831 -112831
PubMed 32961382 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.77	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3622533	FIMEPINOSTAT	2.0	1	8.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3622533	FIMEPINOSTAT	IC50	=	1.7	nM	8.77