Assay Detail

CHEMBL4819320

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of HDAC class1 (unknown origin)

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Class 1 histone deacetylase (CHEMBL4523988) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Class 1 histone deacetylase (CHEMBL4523988) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Class 1 histone deacetylase

CHEMBL4523988

Anchored from Assay target.

Protein identity Class 1 histone deacetylase

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Class 1 histone deacetylase (CHEMBL4523988) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Recent progress on HDAC inhibitors with dual targeting capabilities for cancer treatment.

Peng X, Sun Z, Kuang P, Chen J.
Eur J Med Chem (2020) 208 : 112831 -112831
PubMed 32961382 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.22	8.22

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3989941	TINOSTAMUSTINE	2.0	1	8.22

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3989941	TINOSTAMUSTINE	IC50	=	6.0	nM	8.22