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Assay Detail

CHEMBL4819366

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Functional
Antiproliferative activity against human MCF7 cells incubated for 48 hrs by MTT assay
ChEMBL ↗
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).
Xiao J, Gao M, Sun Z, Diao Q, Wang P, Gao F.
Eur J Med Chem (2020) 208 : 112830 -112830
PubMed 32992133 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 41 6.94 7.38

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4874920 — — 1 7.38
CHEMBL4867243 — — 1 7.38
CHEMBL4876090 — — 1 7.38
CHEMBL4854922 — — 1 7.38
CHEMBL4854851 — — 1 7.38
CHEMBL4871003 — — 1 7.38
CHEMBL4846609 — — 1 7.38
CHEMBL4848535 — — 1 7.38
CHEMBL4876199 — — 1 7.38
CHEMBL4870722 — — 1 7.38
CHEMBL4858424 — — 1 7.38
CHEMBL4872790 — — 1 7.38
CHEMBL4865105 — — 1 7.38
CHEMBL4858761 — — 1 7.38
CHEMBL4847320 — — 1 7.22
CHEMBL4206231 — — 1 7.22
CHEMBL4215547 — — 1 7.22
CHEMBL4855168 — — 1 7.22
CHEMBL4859264 — — 1 6.89
CHEMBL44657 ETOPOSIDE 4.0 1 6.51
CHEMBL4855231 — — 1 6.37
CHEMBL4860055 — — 1 6.31
CHEMBL4869227 — — 1 5.54
CHEMBL4873080 — — 1 4.85
CHEMBL4868066 — — 1 4.85
CHEMBL4874125 — — 1 -
CHEMBL4850550 — — 1 -
CHEMBL4851624 — — 1 -
CHEMBL4877408 — — 1 -
CHEMBL4872751 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4870722 — IC50 = 41.6 nM 7.38
CHEMBL4858761 — IC50 = 41.6 nM 7.38
CHEMBL4865105 — IC50 = 41.6 nM 7.38
CHEMBL4872790 — IC50 = 41.6 nM 7.38
CHEMBL4858424 — IC50 = 41.6 nM 7.38
CHEMBL4876199 — IC50 = 41.6 nM 7.38
CHEMBL4848535 — IC50 = 41.6 nM 7.38
CHEMBL4846609 — IC50 = 41.6 nM 7.38
CHEMBL4871003 — IC50 = 41.6 nM 7.38
CHEMBL4854851 — IC50 = 41.6 nM 7.38
CHEMBL4854922 — IC50 = 41.6 nM 7.38
CHEMBL4876090 — IC50 = 41.6 nM 7.38
CHEMBL4867243 — IC50 = 41.6 nM 7.38
CHEMBL4874920 — IC50 = 41.6 nM 7.38
CHEMBL4855168 — IC50 = 60.0 nM 7.22
CHEMBL4847320 — IC50 = 60.0 nM 7.22
CHEMBL4215547 — IC50 = 60.0 nM 7.22
CHEMBL4206231 — IC50 = 60.0 nM 7.22
CHEMBL4859264 — IC50 = 130.0 nM 6.89
CHEMBL44657 ETOPOSIDE IC50 = 310.0 nM 6.51
CHEMBL4855231 — IC50 = 430.0 nM 6.37
CHEMBL4860055 — IC50 = 490.0 nM 6.31
CHEMBL4869227 — IC50 = 2850.0 nM 5.54
CHEMBL4873080 — IC50 = 14000.0 nM 4.85
CHEMBL4868066 — IC50 = 14000.0 nM 4.85
CHEMBL4854111 — IC50 > 130.0 nM -
CHEMBL4866208 — IC50 > 130.0 nM -
CHEMBL4879117 — IC50 > 130.0 nM -
CHEMBL4854024 — IC50 > 130.0 nM -
CHEMBL4868161 — IC50 > 130.0 nM -
CHEMBL4846588 — IC50 > 130.0 nM -
CHEMBL4878563 — IC50 > 130.0 nM -
CHEMBL447575 — IC50 > 130.0 nM -
CHEMBL4856583 — IC50 > 130.0 nM -
CHEMBL4857528 — IC50 > 2900.0 nM -
CHEMBL4867224 — IC50 > 2900.0 nM -
CHEMBL4872751 — IC50 > 130.0 nM -
CHEMBL4877408 — IC50 > 130.0 nM -
CHEMBL4851624 — IC50 > 130.0 nM -
CHEMBL4850550 — IC50 > 130.0 nM -
CHEMBL4874125 — IC50 > 140.0 nM -