Assay Detail
Functional
CHEMBL4819404
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Antiproliferative activity against human HeLa cells by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances of podophyllotoxin/epipodophyllotoxin hybrids in anticancer activity, mode of action, and structure-activity relationship: An update (2010-2020).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.74 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850811 | — | — | 1 | 7.00 |
| CHEMBL4845962 | — | — | 1 | 7.00 |
| CHEMBL4852246 | — | — | 1 | 7.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.51 |
| CHEMBL4877414 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850811 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4845962 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4852246 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4877414 | — | IC50 | = | 650.0 | nM | 6.19 |