Assay Detail
Functional
CHEMBL4819554
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Anti-inflammatory activity against human PBMCs assessed as inhibition of LPS-induced TNF-alpha production preincubated for 1 hr followed by addition of LPS and measured after 20 hrs by ELISA method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877238 | — | — | 1 | 6.00 |
| CHEMBL4848137 | — | — | 1 | 5.17 |
| CHEMBL4859162 | — | — | 1 | 5.14 |
| CHEMBL4466435 | — | — | 1 | 4.48 |
| CHEMBL4875765 | — | — | 1 | - |
| CHEMBL4857463 | — | — | 1 | - |
| CHEMBL4867813 | — | — | 1 | - |
| CHEMBL4863785 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877238 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4848137 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL4859162 | — | IC50 | = | 7180.0 | nM | 5.14 |
| CHEMBL4466435 | — | IC50 | = | 33340.0 | nM | 4.48 |
| CHEMBL4875765 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4857463 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4867813 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4863785 | — | IC50 | > | 1000.0 | nM | - |