Assay Detail
Binding
CHEMBL4819966
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged VEGFR2 expressed in Baculovirus expression system using ADP-Glo as substrate measured after 30 mins in presence of ATP by ADP-Glo kinase assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.21 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4874971 | — | — | 1 | 4.58 |
| CHEMBL4866291 | — | — | 1 | 4.43 |
| CHEMBL4864168 | — | — | 1 | 4.35 |
| CHEMBL4863263 | — | — | 1 | 4.14 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 4.08 |
| CHEMBL4857454 | — | — | 1 | 4.05 |
| CHEMBL4856891 | — | — | 1 | 4.03 |
| CHEMBL4847439 | — | — | 1 | 4.00 |
| CHEMBL4848005 | — | — | 1 | - |
| CHEMBL4872149 | — | — | 1 | - |
| CHEMBL4856794 | — | — | 1 | - |
| CHEMBL4850246 | — | — | 1 | - |
| CHEMBL4877343 | — | — | 1 | - |
| CHEMBL4869269 | — | — | 1 | - |
| CHEMBL4864073 | — | — | 1 | - |
| CHEMBL4872013 | — | — | 1 | - |
| CHEMBL4878024 | — | — | 1 | - |
| CHEMBL4878880 | — | — | 1 | - |
| CHEMBL4877074 | — | — | 1 | - |
| CHEMBL4853198 | — | — | 1 | - |
| CHEMBL4856663 | — | — | 1 | - |
| CHEMBL4854778 | — | — | 1 | - |
| CHEMBL4871475 | — | — | 1 | - |
| CHEMBL4847210 | — | — | 1 | - |
| CHEMBL4866203 | — | — | 1 | - |
| CHEMBL4866727 | — | — | 1 | - |
| CHEMBL4846157 | — | — | 1 | - |
| CHEMBL4873974 | — | — | 1 | - |
| CHEMBL4876341 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4874971 | — | IC50 | = | 26380.0 | nM | 4.58 |
| CHEMBL4866291 | — | IC50 | = | 36900.0 | nM | 4.43 |
| CHEMBL4864168 | — | IC50 | = | 44670.0 | nM | 4.35 |
| CHEMBL4863263 | — | IC50 | = | 71550.0 | nM | 4.14 |
| CHEMBL535 | SUNITINIB | IC50 | = | 83200.0 | nM | 4.08 |
| CHEMBL4857454 | — | IC50 | = | 89160.0 | nM | 4.05 |
| CHEMBL4856891 | — | IC50 | = | 93110.0 | nM | 4.03 |
| CHEMBL4847439 | — | IC50 | = | 99670.0 | nM | 4.00 |
| CHEMBL4848005 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4872149 | — | IC50 | = | 162810.0 | nM | - |
| CHEMBL4856794 | — | IC50 | = | 115420.0 | nM | - |
| CHEMBL4850246 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4877343 | — | IC50 | = | 198540.0 | nM | - |
| CHEMBL4869269 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4864073 | — | IC50 | = | 108360.0 | nM | - |
| CHEMBL4872013 | — | IC50 | = | 178910.0 | nM | - |
| CHEMBL4878024 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4878880 | — | IC50 | = | 169420.0 | nM | - |
| CHEMBL4877074 | — | IC50 | = | 171120.0 | nM | - |
| CHEMBL4853198 | — | IC50 | = | 192510.0 | nM | - |
| CHEMBL4856663 | — | IC50 | = | 119930.0 | nM | - |
| CHEMBL4854778 | — | IC50 | = | 186440.0 | nM | - |
| CHEMBL4871475 | — | IC50 | = | 170180.0 | nM | - |
| CHEMBL4847210 | — | IC50 | = | 187240.0 | nM | - |
| CHEMBL4866203 | — | IC50 | = | 193410.0 | nM | - |
| CHEMBL4866727 | — | IC50 | = | 190070.0 | nM | - |
| CHEMBL4846157 | — | IC50 | = | 168890.0 | nM | - |
| CHEMBL4873974 | — | IC50 | = | 110600.0 | nM | - |
| CHEMBL4876341 | — | IC50 | = | 139500.0 | nM | - |