Assay Detail
Binding
CHEMBL4820002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at recombinant 6His-tagged thrombin cleavage site of FimH Lectin domain expressed in Escherichia coli HM125 assessed as dissociation constant incubated for 24 hrs in presence of FITC-labeled tracer by competitive fluorescence polarization assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Type 1 fimbrin D-mannose specific adhesin (CHEMBL4837) ↗| Type | SINGLE PROTEIN |
| Organism | Escherichia coli K-12 |
Publication
Does targeting Arg98 of FimH lead to high affinity antagonists?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 26 | 7.12 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4860442 | — | — | 1 | 8.12 |
| CHEMBL4871009 | — | — | 1 | 7.49 |
| CHEMBL1170455 | — | — | 1 | 7.43 |
| CHEMBL4866323 | — | — | 1 | 7.43 |
| CHEMBL4855544 | — | — | 1 | 7.42 |
| CHEMBL4850273 | — | — | 1 | 7.37 |
| CHEMBL4871616 | — | — | 1 | 7.35 |
| CHEMBL4849805 | — | — | 1 | 7.31 |
| CHEMBL4866868 | — | — | 1 | 7.31 |
| CHEMBL4854190 | — | — | 1 | 7.30 |
| CHEMBL4865920 | — | — | 1 | 7.25 |
| CHEMBL4869236 | — | — | 1 | 7.22 |
| CHEMBL4862296 | — | — | 1 | 7.20 |
| CHEMBL4874782 | — | — | 1 | 7.19 |
| CHEMBL4846063 | — | — | 1 | 7.18 |
| CHEMBL4847223 | — | — | 1 | 7.16 |
| CHEMBL4876354 | — | — | 1 | 7.11 |
| CHEMBL4874004 | — | — | 1 | 6.97 |
| CHEMBL4874752 | — | — | 1 | 6.84 |
| CHEMBL4849750 | — | — | 1 | 6.77 |
| CHEMBL4846188 | — | — | 1 | 6.76 |
| CHEMBL4859663 | — | — | 1 | 6.75 |
| CHEMBL1917476 | — | — | 1 | 6.47 |
| CHEMBL4858700 | — | — | 1 | 6.45 |
| CHEMBL4876104 | — | — | 1 | 6.27 |
| CHEMBL4875319 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4860442 | — | Kd | = | 7.6 | nM | 8.12 |
| CHEMBL4871009 | — | Kd | = | 32.6 | nM | 7.49 |
| CHEMBL1170455 | — | Kd | = | 36.8 | nM | 7.43 |
| CHEMBL4866323 | — | Kd | = | 36.7 | nM | 7.43 |
| CHEMBL4855544 | — | Kd | = | 37.8 | nM | 7.42 |
| CHEMBL4850273 | — | Kd | = | 42.8 | nM | 7.37 |
| CHEMBL4871616 | — | Kd | = | 44.7 | nM | 7.35 |
| CHEMBL4849805 | — | Kd | = | 48.8 | nM | 7.31 |
| CHEMBL4866868 | — | Kd | = | 48.5 | nM | 7.31 |
| CHEMBL4854190 | — | Kd | = | 50.6 | nM | 7.30 |
| CHEMBL4865920 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL4869236 | — | Kd | = | 60.7 | nM | 7.22 |
| CHEMBL4862296 | — | Kd | = | 63.3 | nM | 7.20 |
| CHEMBL4874782 | — | Kd | = | 65.0 | nM | 7.19 |
| CHEMBL4846063 | — | Kd | = | 66.2 | nM | 7.18 |
| CHEMBL4847223 | — | Kd | = | 69.1 | nM | 7.16 |
| CHEMBL4876354 | — | Kd | = | 78.5 | nM | 7.11 |
| CHEMBL4874004 | — | Kd | = | 107.0 | nM | 6.97 |
| CHEMBL4874752 | — | Kd | = | 143.0 | nM | 6.84 |
| CHEMBL4849750 | — | Kd | = | 171.0 | nM | 6.77 |
| CHEMBL4846188 | — | Kd | = | 175.0 | nM | 6.76 |
| CHEMBL4859663 | — | Kd | = | 178.0 | nM | 6.75 |
| CHEMBL1917476 | — | Kd | = | 336.0 | nM | 6.47 |
| CHEMBL4858700 | — | Kd | = | 356.0 | nM | 6.45 |
| CHEMBL4876104 | — | Kd | = | 533.0 | nM | 6.27 |
| CHEMBL4875319 | — | Kd | > | 1000.0 | nM | - |