Assay Detail
Binding
CHEMBL4820036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FXR (unknown origin)/human RXR heterodimer expressing in human HepG2 cells co-expressing pCMV gal assessed luciferase activity measured after 24 hrs by by cell based luciferase transactivation assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.50 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4863387 | — | — | 1 | 6.71 |
| CHEMBL318457 | — | — | 1 | 6.53 |
| CHEMBL4869657 | — | — | 1 | 6.42 |
| CHEMBL4860451 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4863387 | — | EC50 | = | 196.0 | nM | 6.71 |
| CHEMBL318457 | — | EC50 | = | 296.0 | nM | 6.53 |
| CHEMBL4869657 | — | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL4860451 | — | EC50 | = | 463.0 | nM | 6.33 |