Assay Detail
Functional
CHEMBL4820101
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Antiproliferative activity against human SK-BR-3 cells assessed as cell viability measured after 72 hrs by MTS method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel 2-aryl-3-sulfonamido-pyridines (HoAns) as microtubule polymerization inhibitors with potent antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.14 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20684 | ABT-751 | 2.0 | 1 | 6.84 |
| CHEMBL4877219 | — | — | 1 | 6.37 |
| CHEMBL4847519 | — | — | 1 | 6.13 |
| CHEMBL4867547 | — | — | 1 | 5.20 |
| CHEMBL4869705 | — | — | 1 | - |
| CHEMBL4851436 | — | — | 1 | - |
| CHEMBL4853094 | — | — | 1 | - |
| CHEMBL4877519 | — | — | 1 | - |
| CHEMBL4858984 | — | — | 1 | - |
| CHEMBL4869761 | — | — | 1 | - |
| CHEMBL4875000 | — | — | 1 | - |
| CHEMBL4864718 | — | — | 1 | - |
| CHEMBL4866169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20684 | ABT-751 | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4877219 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL4847519 | — | IC50 | = | 746.0 | nM | 6.13 |
| CHEMBL4867547 | — | IC50 | = | 6307.0 | nM | 5.20 |
| CHEMBL4869705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4851436 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4853094 | — | IC50 | - | — | - | |
| CHEMBL4877519 | — | IC50 | - | — | - | |
| CHEMBL4858984 | — | IC50 | - | — | - | |
| CHEMBL4869761 | — | IC50 | - | — | - | |
| CHEMBL4875000 | — | IC50 | - | — | - | |
| CHEMBL4864718 | — | IC50 | - | — | - | |
| CHEMBL4866169 | — | IC50 | - | — | - |