Assay Detail
Binding
CHEMBL4820208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by measuring vincristine IC50 at 5 uM measured after 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KBV |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.25 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 8.48 |
| CHEMBL4863423 | — | — | 1 | 8.40 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 8.34 |
| CHEMBL4161103 | — | — | 1 | 7.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 3.34 | nM | 8.48 |
| CHEMBL4863423 | — | IC50 | = | 4.02 | nM | 8.40 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 4.59 | nM | 8.34 |
| CHEMBL4161103 | — | IC50 | = | 16.58 | nM | 7.78 |