Assay Detail
Binding
CHEMBL4820227
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Inhibition of human MAO-B preincubated for 5 mins followed by addition of Kynuramine substrate and measured after 30 mins by plate reader method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.58 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866391 | — | — | 1 | 7.30 |
| CHEMBL673 | PARGYLINE | 4.0 | 1 | 7.10 |
| CHEMBL4862113 | — | — | 1 | 6.85 |
| CHEMBL2334460 | — | — | 1 | 6.57 |
| CHEMBL4858292 | — | — | 1 | 5.06 |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866391 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL673 | PARGYLINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4862113 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2334460 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4858292 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - |