Assay Detail
Functional
CHEMBL4820236
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Cytotoxicity against mouse SIM-A9 cells measured after 24 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | SIM-A9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.86 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4872400 | — | — | 1 | 5.28 |
| CHEMBL4862113 | — | — | 1 | 5.14 |
| CHEMBL4866391 | — | — | 1 | 4.98 |
| CHEMBL2334460 | — | — | 1 | 4.46 |
| CHEMBL4858292 | — | — | 1 | 4.44 |
| CHEMBL4878660 | — | — | 1 | - |
| CHEMBL4868518 | — | — | 1 | - |
| CHEMBL4866040 | — | — | 1 | - |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4872400 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4862113 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4866391 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL2334460 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL4858292 | — | IC50 | = | 36100.0 | nM | 4.44 |
| CHEMBL4878660 | — | IC50 | > | 64000.0 | nM | - |
| CHEMBL4868518 | — | IC50 | > | 32000.0 | nM | - |
| CHEMBL4866040 | — | IC50 | = | 115600.0 | nM | - |
| CHEMBL887 | RASAGILINE | IC50 | = | 2900000.0 | nM | - |