Assay Detail
Binding
CHEMBL4820816
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at RORgammat in mouse Th17 cells assessed as inhibition of CD3/CD28/IL-1/IL-23-induced IL-17A production measured after 24 hrs by AlphaLISA assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Th17 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.27 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4761772 | — | — | 1 | 8.57 |
| CHEMBL4871326 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4761772 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4871326 | — | EC50 | = | 11.0 | nM | 7.96 |