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Assay Detail

CHEMBL4820922

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Binding
Binding affinity to recombinant human HSP90alpha by surface plasmon resonance analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Heat shock protein HSP 90-alpha (CHEMBL3880)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Limonoids from <i>Guarea guidonia</i> and <i>Cedrela odorata</i>: Heat Shock Protein 90 (Hsp90) Modulator Properties of Chisomicine D.
Bellone ML, Muñoz Camero C, Chini MG, Dal Piaz F, Hernandez V, Bifulco G, De Tommasi N, Braca A.
J Nat Prod (2021) 84 : 724 -737
PubMed 33661631 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 15 7.67 8.74

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL414883 RADICICOL 1 8.74
CHEMBL4850751 1 7.74
CHEMBL4865803 1 7.61
CHEMBL4869402 1 7.60
CHEMBL4870060 1 7.59
CHEMBL4854981 1 6.74
CHEMBL4868495 1 -
CHEMBL4850679 1 -
CHEMBL4863699 1 -
CHEMBL4872355 1 -
CHEMBL4847723 1 -
CHEMBL4850598 1 -
CHEMBL4875445 1 -
CHEMBL4878280 1 -
CHEMBL1081393 PROCERANOLIDE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL414883 RADICICOL Kd = 1.8 nM 8.74
CHEMBL4850751 Kd = 18.2 nM 7.74
CHEMBL4865803 Kd = 24.8 nM 7.61
CHEMBL4869402 Kd = 25.3 nM 7.60
CHEMBL4870060 Kd = 25.5 nM 7.59
CHEMBL4854981 Kd = 182.8 nM 6.74
CHEMBL4868495 Kd - -
CHEMBL4850679 Kd - -
CHEMBL4863699 Kd - -
CHEMBL4872355 Kd - -
CHEMBL4847723 Kd - -
CHEMBL4850598 Kd - -
CHEMBL4875445 Kd - -
CHEMBL4878280 Kd - -
CHEMBL1081393 PROCERANOLIDE Kd - -