Assay Detail

CHEMBL4820923

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Functional

Cytotoxicity against human U937 cells assessed as reduction in cell viability after 48 hrs by MTT assay

ChEMBL ↗

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Target

U-937 (CHEMBL612794) ↗

Open DB target context

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Primary target U-937

CHEMBL612794

Anchored from Assay target.

Protein identity U-937

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	U-937
Confidence	1 — Organism
Curated By	Autocuration

Target

U-937 (CHEMBL612794) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Limonoids from <i>Guarea guidonia</i> and <i>Cedrela odorata</i>: Heat Shock Protein 90 (Hsp90) Modulator Properties of Chisomicine D.

Bellone ML, Muñoz Camero C, Chini MG, Dal Piaz F, Hernandez V, Bifulco G, De Tommasi N, Braca A.
J Nat Prod (2021) 84 : 724 -737
PubMed 33661631 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.70	4.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4850751	—	—	1	4.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4850751	—	IC50	=	20000.0	nM	4.70