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Assay Detail

CHEMBL4821031

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Binding
Inhibition of NS-1in Zika virus
ChEMBL ↗
69
Total Activities
69
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Zika virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Shamim K, Xu M, Hu X, Lee EM, Lu X, Huang R, Shah P, Xu X, Chen CZ, Shen M, Guo H, Chen L, Itkin Z, Eastman RT, Shinn P, Klumpp-Thomas C, Michael S, Simeonov A, Lo DC, Ming GL, Song H, Tang H, Zheng W, Huang W.
Bioorg Med Chem Lett (2021) 40 : 127906 -127906
PubMed 33689873 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 69 5.32 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1448 NICLOSAMIDE 4.0 1 6.24
CHEMBL2088014 — — 1 6.10
CHEMBL593726 — — 1 6.08
CHEMBL4845982 — — 1 5.80
CHEMBL4871515 — — 1 5.80
CHEMBL2313077 — — 1 5.80
CHEMBL3397768 — — 1 5.78
CHEMBL4466997 — — 1 5.77
CHEMBL4873480 — — 1 5.76
CHEMBL4589141 — — 1 5.76
CHEMBL4476635 — — 1 5.66
CHEMBL4869609 — — 1 5.64
CHEMBL4858959 — — 1 5.63
CHEMBL2088010 — — 1 5.60
CHEMBL4876273 — — 1 5.60
CHEMBL464249 — — 1 5.60
CHEMBL4866907 — — 1 5.59
CHEMBL3245897 — — 1 5.58
CHEMBL4853412 — — 1 5.57
CHEMBL4852244 — — 1 5.53
CHEMBL2179172 — — 1 5.52
CHEMBL4869369 — — 1 5.52
CHEMBL4852201 — — 1 5.50
CHEMBL4856477 — — 1 5.45
CHEMBL2088012 — — 1 5.45
CHEMBL4860233 — — 1 5.39
CHEMBL3604895 — — 1 5.35
CHEMBL4854883 — — 1 5.27
CHEMBL4845999 — — 1 5.27
CHEMBL2313078 — — 1 5.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1448 NICLOSAMIDE IC50 = 570.0 nM 6.24
CHEMBL2088014 — IC50 = 800.0 nM 6.10
CHEMBL593726 — IC50 = 840.0 nM 6.08
CHEMBL4845982 — IC50 = 1600.0 nM 5.80
CHEMBL4871515 — IC50 = 1590.0 nM 5.80
CHEMBL2313077 — IC50 = 1600.0 nM 5.80
CHEMBL3397768 — IC50 = 1660.0 nM 5.78
CHEMBL4466997 — IC50 = 1700.0 nM 5.77
CHEMBL4873480 — IC50 = 1740.0 nM 5.76
CHEMBL4589141 — IC50 = 1720.0 nM 5.76
CHEMBL4476635 — IC50 = 2170.0 nM 5.66
CHEMBL4869609 — IC50 = 2290.0 nM 5.64
CHEMBL4858959 — IC50 = 2340.0 nM 5.63
CHEMBL4876273 — IC50 = 2500.0 nM 5.60
CHEMBL2088010 — IC50 = 2500.0 nM 5.60
CHEMBL464249 — IC50 = 2500.0 nM 5.60
CHEMBL4866907 — IC50 = 2570.0 nM 5.59
CHEMBL3245897 — IC50 = 2600.0 nM 5.58
CHEMBL4853412 — IC50 = 2680.0 nM 5.57
CHEMBL4852244 — IC50 = 2960.0 nM 5.53
CHEMBL2179172 — IC50 = 3000.0 nM 5.52
CHEMBL4869369 — IC50 = 3020.0 nM 5.52
CHEMBL4852201 — IC50 = 3140.0 nM 5.50
CHEMBL4856477 — IC50 = 3530.0 nM 5.45
CHEMBL2088012 — IC50 = 3590.0 nM 5.45
CHEMBL4860233 — IC50 = 4100.0 nM 5.39
CHEMBL3604895 — IC50 = 4450.0 nM 5.35
CHEMBL4854883 — IC50 = 5400.0 nM 5.27
CHEMBL4845999 — IC50 = 5400.0 nM 5.27
CHEMBL2313078 — IC50 = 5560.0 nM 5.25
CHEMBL1372394 — IC50 = 5740.0 nM 5.24
CHEMBL4868292 — IC50 = 5840.0 nM 5.23
CHEMBL3604894 — IC50 = 5940.0 nM 5.23
CHEMBL4871496 — IC50 = 6040.0 nM 5.22
CHEMBL4848973 — IC50 = 5960.0 nM 5.22
CHEMBL4875298 — IC50 = 6200.0 nM 5.21
CHEMBL3604898 — IC50 = 6600.0 nM 5.18
CHEMBL4849297 — IC50 = 6830.0 nM 5.17
CHEMBL4876022 — IC50 = 6800.0 nM 5.17
CHEMBL2437347 — IC50 = 8200.0 nM 5.09
CHEMBL2313091 — IC50 = 8370.0 nM 5.08
CHEMBL4875423 — IC50 = 8270.0 nM 5.08
CHEMBL2326743 — IC50 = 9100.0 nM 5.04
CHEMBL4873744 — IC50 = 10500.0 nM 4.98
CHEMBL2312822 — IC50 = 11360.0 nM 4.95
CHEMBL2326742 — IC50 = 11900.0 nM 4.92
CHEMBL4867308 — IC50 = 12500.0 nM 4.90
CHEMBL4563718 — IC50 = 12860.0 nM 4.89
CHEMBL2313135 — IC50 = 13050.0 nM 4.88
CHEMBL4850839 — IC50 = 13370.0 nM 4.87