Assay Detail
Functional
CHEMBL4821036
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Antiviral activity against Zika virus infected in SNB-19 cells assessed as reduction in viral titer
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNB-19 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.16 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL593726 | — | — | 1 | 6.96 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 6.92 |
| CHEMBL2312822 | — | — | 1 | 6.40 |
| CHEMBL2088010 | — | — | 1 | 6.09 |
| CHEMBL4563718 | — | — | 1 | 6.09 |
| CHEMBL4466997 | — | — | 1 | 6.09 |
| CHEMBL464249 | — | — | 1 | 6.08 |
| CHEMBL2088014 | — | — | 1 | 5.75 |
| CHEMBL4871515 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL593726 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1448 | NICLOSAMIDE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2312822 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2088010 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4563718 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4466997 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL464249 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL2088014 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4871515 | — | IC50 | = | 8600.0 | nM | 5.07 |