Assay Detail
Binding
CHEMBL4821052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to dopamine D2 receptor (unknown origin)
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.31 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4870716 | — | — | 1 | 8.82 |
| CHEMBL4865907 | — | — | 1 | 8.77 |
| CHEMBL4846866 | — | — | 1 | 8.72 |
| CHEMBL4860828 | — | — | 1 | 8.72 |
| CHEMBL4878271 | — | — | 1 | 8.70 |
| CHEMBL4856753 | — | — | 1 | 8.70 |
| CHEMBL4853342 | — | — | 1 | 8.60 |
| CHEMBL2387229 | — | — | 1 | 8.59 |
| CHEMBL4873319 | — | — | 1 | 8.59 |
| CHEMBL4861643 | — | — | 1 | 8.57 |
| CHEMBL4289498 | — | — | 1 | 8.54 |
| CHEMBL4877973 | — | — | 1 | 8.51 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.41 |
| CHEMBL3883955 | — | — | 1 | 8.30 |
| CHEMBL4863980 | — | — | 1 | 8.27 |
| CHEMBL4877940 | — | — | 1 | 8.21 |
| CHEMBL4861193 | — | — | 1 | 8.13 |
| CHEMBL4870307 | — | — | 1 | 8.02 |
| CHEMBL4861311 | — | — | 1 | 8.01 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.01 |
| CHEMBL4859348 | — | — | 1 | 7.99 |
| CHEMBL4867978 | — | — | 1 | 7.98 |
| CHEMBL4865735 | — | — | 1 | 7.97 |
| CHEMBL4876719 | — | — | 1 | 7.94 |
| CHEMBL4852663 | — | — | 1 | 7.91 |
| CHEMBL4857350 | — | — | 1 | 7.90 |
| CHEMBL4857918 | — | — | 1 | 7.87 |
| CHEMBL4879054 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4870716 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4865907 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4846866 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4860828 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4878271 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4856753 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4853342 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL2387229 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4873319 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4861643 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4289498 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL4877973 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL85 | RISPERIDONE | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL3883955 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4863980 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL4877940 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL4861193 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL4870307 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL4861311 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL4859348 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL4867978 | — | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL4865735 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL4876719 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL4852663 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL4857350 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL4857918 | — | Ki | = | 13.4 | nM | 7.87 |
| CHEMBL4879054 | — | Ki | = | 14.1 | nM | 7.85 |