Assay Detail
Binding
CHEMBL4821053
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Binding affinity to dopamine D3 receptor (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.92 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4289498 | — | — | 1 | 8.77 |
| CHEMBL2387229 | — | — | 1 | 8.37 |
| CHEMBL4867978 | — | — | 1 | 8.02 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.97 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.84 |
| CHEMBL4861311 | — | — | 1 | 7.82 |
| CHEMBL4865907 | — | — | 1 | 7.63 |
| CHEMBL3883955 | — | — | 1 | 7.45 |
| CHEMBL4846866 | — | — | 1 | 7.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4289498 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL2387229 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4867978 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL85 | RISPERIDONE | Ki | = | 14.3 | nM | 7.84 |
| CHEMBL4861311 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL4865907 | — | Ki | = | 23.2 | nM | 7.63 |
| CHEMBL3883955 | — | Ki | = | 35.7 | nM | 7.45 |
| CHEMBL4846866 | — | Ki | = | 37.6 | nM | 7.42 |