Assay Detail
Binding
CHEMBL4821055
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Binding affinity to 5-HT2A receptor (unknown origin)
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 8.33 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 9.72 |
| CHEMBL3883955 | — | — | 1 | 9.52 |
| CHEMBL2387229 | — | — | 1 | 9.52 |
| CHEMBL4289498 | — | — | 1 | 9.15 |
| CHEMBL4846866 | — | — | 1 | 8.37 |
| CHEMBL4870716 | — | — | 1 | 8.36 |
| CHEMBL4856753 | — | — | 1 | 8.35 |
| CHEMBL4865907 | — | — | 1 | 8.33 |
| CHEMBL4873319 | — | — | 1 | 8.31 |
| CHEMBL4861643 | — | — | 1 | 8.29 |
| CHEMBL4865735 | — | — | 1 | 8.29 |
| CHEMBL4877973 | — | — | 1 | 8.29 |
| CHEMBL4878271 | — | — | 1 | 8.28 |
| CHEMBL4860828 | — | — | 1 | 8.25 |
| CHEMBL4853342 | — | — | 1 | 8.24 |
| CHEMBL4876719 | — | — | 1 | 8.21 |
| CHEMBL4863980 | — | — | 1 | 8.20 |
| CHEMBL4859348 | — | — | 1 | 8.19 |
| CHEMBL4867978 | — | — | 1 | 8.08 |
| CHEMBL4857918 | — | — | 1 | 8.07 |
| CHEMBL4852663 | — | — | 1 | 8.07 |
| CHEMBL4870307 | — | — | 1 | 8.05 |
| CHEMBL4861311 | — | — | 1 | 8.03 |
| CHEMBL4879054 | — | — | 1 | 8.00 |
| CHEMBL4877940 | — | — | 1 | 7.97 |
| CHEMBL4857350 | — | — | 1 | 7.94 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.92 |
| CHEMBL4861193 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL3883955 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL2387229 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4289498 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL4846866 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4870716 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL4856753 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL4865907 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL4873319 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL4861643 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4865735 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4877973 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4878271 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL4860828 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL4853342 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4876719 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL4863980 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4859348 | — | Ki | = | 6.5 | nM | 8.19 |
| CHEMBL4867978 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL4857918 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL4852663 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL4870307 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL4861311 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL4879054 | — | Ki | = | 10.1 | nM | 8.00 |
| CHEMBL4877940 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL4857350 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 12.1 | nM | 7.92 |
| CHEMBL4861193 | — | Ki | = | 42.9 | nM | 7.37 |