Assay Detail
Binding
CHEMBL4821057
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Binding affinity to 5-HT6 receptor (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.13 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3883955 | — | — | 1 | 9.30 |
| CHEMBL4289498 | — | — | 1 | 8.25 |
| CHEMBL4865907 | — | — | 1 | 7.03 |
| CHEMBL4846866 | — | — | 1 | 6.91 |
| CHEMBL4867978 | — | — | 1 | 6.85 |
| CHEMBL4861311 | — | — | 1 | 6.83 |
| CHEMBL2387229 | — | — | 1 | 6.64 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 6.50 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 5.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3883955 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL4289498 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL4865907 | — | Ki | = | 93.3 | nM | 7.03 |
| CHEMBL4846866 | — | Ki | = | 122.7 | nM | 6.91 |
| CHEMBL4867978 | — | Ki | = | 141.0 | nM | 6.85 |
| CHEMBL4861311 | — | Ki | = | 149.2 | nM | 6.83 |
| CHEMBL2387229 | — | Ki | = | 228.4 | nM | 6.64 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL85 | RISPERIDONE | Ki | = | 1329.2 | nM | 5.88 |