Assay Detail
ADMET
CHEMBL4821058
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to alpha1 adrenoceptor (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.84 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.49 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 8.05 |
| CHEMBL4289498 | — | — | 1 | 7.37 |
| CHEMBL4865907 | — | — | 1 | 6.48 |
| CHEMBL3883955 | — | — | 1 | 6.47 |
| CHEMBL4846866 | — | — | 1 | 6.45 |
| CHEMBL4867978 | — | — | 1 | 6.36 |
| CHEMBL4861311 | — | — | 1 | 6.27 |
| CHEMBL2387229 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL4289498 | — | Ki | = | 43.1 | nM | 7.37 |
| CHEMBL4865907 | — | Ki | = | 331.5 | nM | 6.48 |
| CHEMBL3883955 | — | Ki | = | 337.2 | nM | 6.47 |
| CHEMBL4846866 | — | Ki | = | 353.6 | nM | 6.45 |
| CHEMBL4867978 | — | Ki | = | 438.2 | nM | 6.36 |
| CHEMBL4861311 | — | Ki | = | 536.1 | nM | 6.27 |
| CHEMBL2387229 | — | Ki | = | 2569.2 | nM | 5.59 |