Assay Detail
ADMET
CHEMBL4821059
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to histamine H1 receptor (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a new class of multi-target heterocycle piperidine derivatives as potential antipsychotics with pro-cognitive effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.33 | 7.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 7.49 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.31 |
| CHEMBL4289498 | — | — | 1 | 6.20 |
| CHEMBL4846866 | — | — | 1 | 6.19 |
| CHEMBL4865907 | — | — | 1 | 6.14 |
| CHEMBL4867978 | — | — | 1 | 6.01 |
| CHEMBL4861311 | — | — | 1 | 5.99 |
| CHEMBL2387229 | — | — | 1 | 5.95 |
| CHEMBL3883955 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85 | RISPERIDONE | Ki | = | 32.6 | nM | 7.49 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 48.9 | nM | 7.31 |
| CHEMBL4289498 | — | Ki | = | 630.1 | nM | 6.20 |
| CHEMBL4846866 | — | Ki | = | 642.4 | nM | 6.19 |
| CHEMBL4865907 | — | Ki | = | 719.5 | nM | 6.14 |
| CHEMBL4867978 | — | Ki | = | 968.3 | nM | 6.01 |
| CHEMBL4861311 | — | Ki | = | 1016.5 | nM | 5.99 |
| CHEMBL2387229 | — | Ki | = | 1125.3 | nM | 5.95 |
| CHEMBL3883955 | — | Ki | = | 1998.0 | nM | 5.70 |