Assay Detail
Binding
CHEMBL4821172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BACE1 (1 to 454 residues) (unknown origin) using APP harboring Swedish Lys/Met mutant-derived peptide as substrate by FRET assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective β-Secretase (BACE1) Inhibitors over BACE2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.61 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3301601 | VERUBECESTAT | 3.0 | 1 | 8.72 |
| CHEMBL4864591 | — | — | 1 | 7.82 |
| CHEMBL4854629 | — | — | 1 | 7.62 |
| CHEMBL2347203 | — | — | 1 | 7.50 |
| CHEMBL4852444 | — | — | 1 | 7.15 |
| CHEMBL4856391 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3301601 | VERUBECESTAT | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL4864591 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4854629 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2347203 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4852444 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4856391 | — | IC50 | = | 145.0 | nM | 6.84 |