Assay Detail
ADMET
CHEMBL4821235
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Cytotoxicity against human PCS-800-011 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | PCS-800-011 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.46 | 4.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4877452 | — | — | 1 | 4.76 |
| CHEMBL4849859 | — | — | 1 | 4.50 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 4.49 |
| CHEMBL4859473 | — | — | 1 | 4.43 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 4.39 |
| CHEMBL4866476 | — | — | 1 | 4.35 |
| CHEMBL1988225 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4877452 | — | IC50 | = | 17280.0 | nM | 4.76 |
| CHEMBL4849859 | — | IC50 | = | 31350.0 | nM | 4.50 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 32240.0 | nM | 4.49 |
| CHEMBL4859473 | — | IC50 | = | 36850.0 | nM | 4.43 |
| CHEMBL939 | GEFITINIB | IC50 | = | 40780.0 | nM | 4.39 |
| CHEMBL4866476 | — | IC50 | = | 44340.0 | nM | 4.35 |
| CHEMBL1988225 | — | IC50 | = | 51230.0 | nM | 4.29 |