Assay Detail
Functional
CHEMBL4821236
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Cytotoxicity against human A549 cells incubated for 2 to 4 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.15 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4866476 | — | — | 1 | 6.14 |
| CHEMBL4859473 | — | — | 1 | 5.68 |
| CHEMBL4877452 | — | — | 1 | 5.49 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.45 |
| CHEMBL4849859 | — | — | 1 | 5.28 |
| CHEMBL1988225 | — | — | 1 | 5.14 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.00 |
| CHEMBL4865719 | — | — | 1 | 4.88 |
| CHEMBL4873968 | — | — | 1 | 4.67 |
| CHEMBL4869732 | — | — | 1 | 4.60 |
| CHEMBL4855214 | — | — | 1 | 4.35 |
| CHEMBL1969820 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4866476 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL4859473 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4877452 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4849859 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL1988225 | — | IC50 | = | 7290.0 | nM | 5.14 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4865719 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4873968 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL4869732 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL4855214 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL1969820 | — | IC50 | = | 187000.0 | nM | - |