Assay Detail
Functional
CHEMBL4821397
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Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel pyrimidine molecules containing boronic acid as VCP/p97 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.68 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747513 | CB-5083 | 1.0 | 1 | 6.10 |
| CHEMBL4871978 | — | — | 1 | 6.07 |
| CHEMBL4848009 | — | — | 1 | 5.90 |
| CHEMBL4872975 | — | — | 1 | 5.82 |
| CHEMBL4862740 | — | — | 1 | 5.81 |
| CHEMBL4854511 | — | — | 1 | 5.76 |
| CHEMBL4847081 | — | — | 1 | 5.72 |
| CHEMBL4864700 | — | — | 1 | 5.66 |
| CHEMBL4858461 | — | — | 1 | 5.64 |
| CHEMBL4859176 | — | — | 1 | 5.63 |
| CHEMBL4846448 | — | — | 1 | 5.62 |
| CHEMBL4871208 | — | — | 1 | 5.57 |
| CHEMBL4877447 | — | — | 1 | 5.54 |
| CHEMBL4859015 | — | — | 1 | 5.53 |
| CHEMBL4847502 | — | — | 1 | 5.50 |
| CHEMBL4876550 | — | — | 1 | 5.44 |
| CHEMBL4858094 | — | — | 1 | 5.29 |
| CHEMBL4878519 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747513 | CB-5083 | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4871978 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4848009 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4872975 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4862740 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL4854511 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL4847081 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4864700 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4858461 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4859176 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL4846448 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4871208 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4877447 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4859015 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL4847502 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4876550 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4858094 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4878519 | — | IC50 | - | — | - |