Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4821473

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-5CT from human 5-HT7R expressed in human HEK293 cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 7 (CHEMBL3155)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Radioligand and computational insight in structure - Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues.
Kułaga D, Jaśkowska J, Satała G.
Bioorg Med Chem Lett (2021) 42 : 128028 -128028
PubMed 33839253 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 6.60 7.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4874914 1 7.46
CHEMBL4866981 1 7.44
CHEMBL4876545 1 7.01
CHEMBL4565558 1 6.98
CHEMBL4860754 1 6.90
CHEMBL4872713 1 6.83
CHEMBL4869198 1 6.83
CHEMBL4853700 1 6.75
CHEMBL4867109 1 6.72
CHEMBL4860626 1 6.43
CHEMBL4439795 1 6.31
CHEMBL4569757 1 6.31
CHEMBL8412 IPSAPIRONE 2.0 1 5.85
CHEMBL4470487 1 5.60
CHEMBL4873100 1 5.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4874914 Ki = 35.0 nM 7.46
CHEMBL4866981 Ki = 36.0 nM 7.44
CHEMBL4876545 Ki = 97.0 nM 7.01
CHEMBL4565558 Ki = 105.0 nM 6.98
CHEMBL4860754 Ki = 125.0 nM 6.90
CHEMBL4872713 Ki = 148.0 nM 6.83
CHEMBL4869198 Ki = 149.0 nM 6.83
CHEMBL4853700 Ki = 179.0 nM 6.75
CHEMBL4867109 Ki = 191.0 nM 6.72
CHEMBL4860626 Ki = 372.0 nM 6.43
CHEMBL4439795 Ki = 487.0 nM 6.31
CHEMBL4569757 Ki = 487.0 nM 6.31
CHEMBL8412 IPSAPIRONE Ki = 1406.0 nM 5.85
CHEMBL4470487 Ki = 2515.0 nM 5.60
CHEMBL4873100 Ki = 2673.0 nM 5.57