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Assay Detail

CHEMBL4821480

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-ketanserin from human 5-HT2AR expressed in CHO cells
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

5-hydroxytryptamine receptor 2A (CHEMBL224)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Radioligand and computational insight in structure - Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues.
Kułaga D, Jaśkowska J, Satała G.
Bioorg Med Chem Lett (2021) 42 : 128028 -128028
PubMed 33839253 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 6.16 6.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4866981 1 6.98
CHEMBL4869198 1 6.90
CHEMBL4867109 1 6.86
CHEMBL4874914 1 6.79
CHEMBL4470487 1 6.74
CHEMBL4569757 1 6.52
CHEMBL4439795 1 6.52
CHEMBL4872713 1 6.50
CHEMBL4860754 1 6.23
CHEMBL4849583 1 6.16
CHEMBL4565558 1 6.12
CHEMBL4853700 1 5.84
CHEMBL238916 1 5.65
CHEMBL4860626 1 5.59
CHEMBL4876545 1 5.32
CHEMBL4873100 1 5.20
CHEMBL8412 IPSAPIRONE 2.0 1 4.82
CHEMBL4853248 1 -
CHEMBL238917 1 -
CHEMBL238915 1 -
CHEMBL394110 1 -
CHEMBL2107024 REVOSPIRONE 2.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4866981 Ki = 105.0 nM 6.98
CHEMBL4869198 Ki = 126.0 nM 6.90
CHEMBL4867109 Ki = 139.0 nM 6.86
CHEMBL4874914 Ki = 162.0 nM 6.79
CHEMBL4470487 Ki = 183.0 nM 6.74
CHEMBL4569757 Ki = 299.0 nM 6.52
CHEMBL4439795 Ki = 299.0 nM 6.52
CHEMBL4872713 Ki = 313.0 nM 6.50
CHEMBL4860754 Ki = 584.0 nM 6.23
CHEMBL4849583 Ki = 700.0 nM 6.16
CHEMBL4565558 Ki = 764.0 nM 6.12
CHEMBL4853700 Ki = 1438.0 nM 5.84
CHEMBL238916 Ki = 2250.0 nM 5.65
CHEMBL4860626 Ki = 2580.0 nM 5.59
CHEMBL4876545 Ki = 4754.0 nM 5.32
CHEMBL4873100 Ki = 6306.0 nM 5.20
CHEMBL8412 IPSAPIRONE Ki = 14980.0 nM 4.82
CHEMBL4853248 Ki - -
CHEMBL238917 Ki - -
CHEMBL238915 Ki - -
CHEMBL394110 Ki - -
CHEMBL2107024 REVOSPIRONE Ki - -