Assay Detail
Functional
CHEMBL4821680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human NCI-H1299 cells assessed as reduction in cell viability after 72 hrs by MTT assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1299 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.07 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4850687 | — | — | 1 | 5.60 |
| CHEMBL4878335 | — | — | 1 | 5.13 |
| CHEMBL4872839 | — | — | 1 | 5.13 |
| CHEMBL4849480 | — | — | 1 | 5.08 |
| CHEMBL4860767 | — | — | 1 | 5.07 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.05 |
| CHEMBL4860017 | — | — | 1 | 5.05 |
| CHEMBL4854832 | — | — | 1 | 4.79 |
| CHEMBL4855239 | — | — | 1 | 4.72 |
| CHEMBL4870134 | — | — | 1 | - |
| CHEMBL3943980 | — | — | 1 | - |
| CHEMBL4860131 | — | — | 1 | - |
| CHEMBL4861916 | — | — | 1 | - |
| CHEMBL4869974 | — | — | 1 | - |
| CHEMBL4858234 | — | — | 1 | - |
| CHEMBL4872623 | — | — | 1 | - |
| CHEMBL4862374 | — | — | 1 | - |
| CHEMBL4872089 | — | — | 1 | - |
| CHEMBL4858929 | — | — | 1 | - |
| CHEMBL4874775 | — | — | 1 | - |
| CHEMBL4864684 | — | — | 1 | - |
| CHEMBL4861258 | — | — | 1 | - |
| CHEMBL4846785 | — | — | 1 | - |
| CHEMBL4858638 | — | — | 1 | - |
| CHEMBL4876422 | — | — | 1 | - |
| CHEMBL4860867 | — | — | 1 | - |
| CHEMBL4866230 | — | — | 1 | - |
| CHEMBL4877487 | — | — | 1 | - |
| CHEMBL4871442 | — | — | 1 | - |
| CHEMBL4848560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4850687 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL4878335 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL4872839 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL4849480 | — | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL4860767 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL4860017 | — | IC50 | = | 8880.0 | nM | 5.05 |
| CHEMBL4854832 | — | IC50 | = | 16080.0 | nM | 4.79 |
| CHEMBL4855239 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL4872623 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4866843 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4862374 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4872089 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4858929 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4858053 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4853891 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4847880 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4866629 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4862513 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4860457 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4853970 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4859790 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4869084 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4867557 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4851876 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4861258 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4848560 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4871442 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4877487 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4866230 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4860867 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4876422 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4858638 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4846785 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4858234 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4864684 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4874775 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4870134 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3943980 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4860131 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4861916 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4869974 | — | IC50 | > | 20000.0 | nM | - |