Assay Detail
Functional
CHEMBL4821683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.27 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 6.47 |
| CHEMBL4850687 | — | — | 1 | 6.42 |
| CHEMBL4860867 | — | — | 1 | 5.62 |
| CHEMBL4854832 | — | — | 1 | 5.37 |
| CHEMBL4878335 | — | — | 1 | 5.28 |
| CHEMBL4872839 | — | — | 1 | 5.26 |
| CHEMBL4864684 | — | — | 1 | 4.94 |
| CHEMBL4858638 | — | — | 1 | 4.91 |
| CHEMBL4860017 | — | — | 1 | 4.84 |
| CHEMBL4870134 | — | — | 1 | 4.80 |
| CHEMBL4846785 | — | — | 1 | 4.78 |
| CHEMBL4860131 | — | — | 1 | 4.59 |
| CHEMBL4853891 | — | — | 1 | - |
| CHEMBL4858053 | — | — | 1 | - |
| CHEMBL4858929 | — | — | 1 | - |
| CHEMBL4872089 | — | — | 1 | - |
| CHEMBL4862374 | — | — | 1 | - |
| CHEMBL4872623 | — | — | 1 | - |
| CHEMBL4858234 | — | — | 1 | - |
| CHEMBL4869974 | — | — | 1 | - |
| CHEMBL4862513 | — | — | 1 | - |
| CHEMBL4866629 | — | — | 1 | - |
| CHEMBL4848560 | — | — | 1 | - |
| CHEMBL4877487 | — | — | 1 | - |
| CHEMBL4866230 | — | — | 1 | - |
| CHEMBL4876422 | — | — | 1 | - |
| CHEMBL3943980 | — | — | 1 | - |
| CHEMBL4874775 | — | — | 1 | - |
| CHEMBL4871442 | — | — | 1 | - |
| CHEMBL4861258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4850687 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4860867 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL4854832 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL4878335 | — | IC50 | = | 5220.0 | nM | 5.28 |
| CHEMBL4872839 | — | IC50 | = | 5480.0 | nM | 5.26 |
| CHEMBL4864684 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4858638 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4860017 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4870134 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL4846785 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4860131 | — | IC50 | = | 25670.0 | nM | 4.59 |
| CHEMBL4858929 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4851876 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4858053 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4853891 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4847880 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4861916 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4866843 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4860767 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4860457 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4853970 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4855239 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4859790 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4869084 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4849480 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4867557 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4872089 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4862374 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4872623 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4858234 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4869974 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4862513 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4866629 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4848560 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4877487 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4866230 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4876422 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3943980 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4874775 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4871442 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4861258 | — | IC50 | > | 20000.0 | nM | - |