Assay Detail
Binding
CHEMBL4821693
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK4/Cyclin D3 (unknown origin) by mobility shift assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.34 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 8.46 |
| CHEMBL4850687 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 3.44 | nM | 8.46 |
| CHEMBL4850687 | — | IC50 | = | 6.1 | nM | 8.21 |