Assay Detail
Functional
CHEMBL4821766
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Antiproliferative activity against human CT26 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CT26 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.68 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4873148 | — | — | 1 | 5.10 |
| CHEMBL4865930 | — | — | 1 | 4.93 |
| CHEMBL4850099 | — | — | 1 | 4.80 |
| CHEMBL4859501 | — | — | 1 | 4.67 |
| CHEMBL4875215 | — | — | 1 | 4.64 |
| CHEMBL1957266 | — | — | 1 | 4.54 |
| CHEMBL4637198 | — | — | 1 | 4.44 |
| CHEMBL3987016 | MIVEBRESIB | 2.0 | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4873148 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL4865930 | — | IC50 | = | 11770.0 | nM | 4.93 |
| CHEMBL4850099 | — | IC50 | = | 15770.0 | nM | 4.80 |
| CHEMBL4859501 | — | IC50 | = | 21180.0 | nM | 4.67 |
| CHEMBL4875215 | — | IC50 | = | 22890.0 | nM | 4.64 |
| CHEMBL1957266 | — | IC50 | = | 28670.0 | nM | 4.54 |
| CHEMBL4637198 | — | IC50 | = | 35980.0 | nM | 4.44 |
| CHEMBL3987016 | MIVEBRESIB | IC50 | = | 48260.0 | nM | 4.32 |